Ventilation and air circulation are essential elements in healthcare facilities. Moreover, good ventilation helps to dilute odour pollutants and control the spread of the disease. This air circulation generally uses mechanical ventilation, whereas the use of natural ventilation is encouraged by the Indonesian Ministry of Health and the World Health Organization due to its affordability and sustainability considerations. Therefore, this paper aims to study the optimal building composition for health facilities using natural ventilation. There are two parts of the discussion in this manuscript. The first part is to study the building shape based on local wind characteristics. The second part is to determine the layout of the interior, adapting to the prevailing wind and its function. The research approach uses venturi theory, solar atrium and cross-ventilation, which is simulated through several computer simulations. The result showed that by orchestrating the building composition and layout in a specific way, natural ventilation could remove disease particles and provide better air circulation. These findings can be a new discussion in the planning and design of health facilities due to natural ventilation.